How does mesothelioma develop?

Mesothelioma develops primarily as a result of exposure to asbestos, where asbestos fibers penetrate lung tissues and can subsequently spread to nearby areas. When these microscopic fibers are inhaled, they can become lodged in the lining of the lungs or abdomen, known as the mesothelium. Over time, this exposure can cause significant damage to the cells of the mesothelium, leading to inflammation and eventually the development of mesothelioma. The disease typically has a long latency period, meaning symptoms may not appear until many years after the initial exposure to asbestos.

In contrast, smoking tobacco products is associated with lung cancer and other respiratory diseases but is not linked to mesothelioma. Viral infections and exposure to heavy metals are also not considered causes of mesothelioma; while they may contribute to other health issues, their roles in the development of this specific type of cancer are not supported by significant evidence. Thus, the route of asbestos fibers penetrating lung tissues is the key mechanism through which mesothelioma develops.