What is a significant drawback of using Transmission Electron Microscopy (TEM)?

The significant drawback of using Transmission Electron Microscopy (TEM) lies in its high cost and the time-consuming nature of the technique. TEM requires sophisticated equipment and highly trained personnel to operate effectively, leading to elevated operational costs. Additionally, the sample preparation for TEM can be intricate and lengthy, requiring careful handling and processing to ensure the specimen is suitable for analysis at the atomic or molecular level.

Unlike more accessible and quicker methods, the complexities of TEM necessitate a deeper understanding of both the technology and the materials being analyzed, which not only raises expenses but also extends the overall time from sample collection to results delivery. This combination of factors makes TEM less practical for routine analyses or in situations where quick results are essential.